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Browsing Research and Innovation Unit by Subject "Prion"

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The compound (3-{5-[(2,5-dimethoxyphenyl)amino]-1,3,4-thiadiazolidin-2-yl}-5,8-methoxy-2H-chromen-2-one) inhibits the prion protein conversion from PrPC to PrPSc with lower IC50 in ScN2a cells

Pagadala, Nataraj S.; Bjorndahl, Trent C.; Joyce, Michael; Wishart, David S.; Syed, Khajamohiddin; Landi, Abdolamir (Bioorganic & Medicinal Chemistry, 2017)

Prion diseases are fatal neurodegenerative disorders of the central nervous system characterized by the accumulation of a protease resistant form (PrPSc) of the cellular prion protein (PrPC) in the brain. Two types of ...
The compound (3-{5-[(2,5-dimethoxyphenyl)amino]-1,3,4-thiadiazolidin-2-yl}-5,8-methoxy-2H-chromen-2-one) inhibits the prion protein conversion from PrPC to PrPSc with lower IC50 in ScN2a cells

Pagadala, Nataraj S.; Bjorndahl, Trent C.; Joyce, Michael; Wishart, David S.; Syed, Khajamohiddin; Landi, Abdolamir (Elsevier Ltd: Bioorganic & Medicinal Chemistry, 2017)

Prion diseases are fatal neurodegenerative disorders of the central nervous system characterized by the accumulation of a protease resistant form (PrPSc) of the cellular prion protein (PrPC) in the brain. Two types of ...
In silico strategies on prion pathogenic conversion and inhibition from PrPC -PrPSc

Pagadala, Nataraj S.; Syed, Khajamohiddin; Bhat, Rakesh (Taylor & Francis: Expert Opinion on Drug Discovery, 2017)

To date, various therapeutic strategies identified numerous anti-prion compounds and antibodies that stabilize PrPC, block the conversion of PrPC-PrPSc and increased effect on PrPSc clearance. However, no suitable drug has ...

Browsing Research and Innovation Unit by Subject "Prion"

Browsing Research and Innovation Unit by Subject "Prion"

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