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Browsing Research Articles: Faculty of Engineering and Information Technology by Author "Syed, Khajamohiddin"

Browsing Research Articles: Faculty of Engineering and Information Technology by Author "Syed, Khajamohiddin"

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  • The compound (3-{5-[(2,5-dimethoxyphenyl)amino]-1,3,4-thiadiazolidin-2-yl}-5,8-methoxy-2H-chromen-2-one) inhibits the prion protein conversion from PrPC to PrPSc with lower IC50 in ScN2a cells 
    Pagadala, Nataraj S.; Bjorndahl, Trent C.; Joyce, Michael; Wishart, David S.; Syed, Khajamohiddin; Landi, Abdolamir (Bioorganic & Medicinal Chemistry, 2017)
    Prion diseases are fatal neurodegenerative disorders of the central nervous system characterized by the accumulation of a protease resistant form (PrPSc) of the cellular prion protein (PrPC) in the brain. Two types of ...
  • Diversity and evolution of cytochrome P450 monooxygenases in Oomycetes 
    Sello, Mopeli Marshal; Jafta, Norventia; Nelson, David R; Chen, Wanping; Yu, Jae-Hyuk; Parvez, Mohammad; Kgosiemang, Ipeleng Kopano Rosinah; Monyaki, Richie; Raselemane, Seiso Caiphus; Qhanya, Lehlohonolo Benedict; Mthakathi, Ntsane Trevor; Mashele, Samson Sitheni; Syed, Khajamohiddin (Springer Nature Limited: Scientific Reports, 2015)
    Cytochrome P450 monooxygenases (P450s) are heme-thiolate proteins whose role as drug targets against pathogens, as well as in valuable chemical production and bioremediation, has been explored. In this study we performed ...
  • In silico strategies on prion pathogenic conversion and inhibition from PrPC -PrPSc 
    Pagadala, Nataraj S.; Syed, Khajamohiddin; Bhat, Rakesh (Taylor & Francis: Expert Opinion on Drug Discovery, 2017)
    To date, various therapeutic strategies identified numerous anti-prion compounds and antibodies that stabilize PrPC, block the conversion of PrPC-PrPSc and increased effect on PrPSc clearance. However, no suitable drug has ...
  • Software for molecular docking: a review 
    Pagadala, Nataraj S.; Syed, Khajamohiddin; Tuszynski, Jack (Biophysical Reviews, 2017)
    Molecular docking methodology explores the behavior of small molecules in the binding site of a target protein. As more protein structures are determined experimentally using X-ray crystallography or nuclear magnetic ...

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