DSpace Repository

A Comprehensive Review On Zinc(Ii) Complexes As Anti-Diabetic Agents: The Advances, Scientific Gaps And Prospects

Show simple item record

dc.contributor.author Chukwuma, Chika, Ifeanyi.
dc.contributor.author Mashele, Samson, S.
dc.contributor.author Eze, Kenneth, C.
dc.contributor.author Matowane, Godfrey, R.
dc.contributor.author Islam, Shahidul, M.D.
dc.contributor.author Bonnet, Susanna, L.
dc.contributor.author Noreljaleeld, Anwar, E.M.
dc.contributor.author Ramorobi, Limpho, M.
dc.date.accessioned 2023-05-03T10:29:00Z
dc.date.available 2023-05-03T10:29:00Z
dc.date.issued 2020-03-07
dc.identifier.issn 1043-6618
dc.identifier.other https://doi.org/10.1016/j.phrs.2020.104744
dc.identifier.uri http://hdl.handle.net/11462/2450
dc.description Article en_US
dc.description.abstract Zinc has gained notable attention in the development of potent anti-diabetic agents, due to its role in insulin storage and secretion, as well as its reported insulin mimetic properties. Consequently, zinc(II) has been complexed with numerous organic ligands as an adjuvant to develop anti-diabetic agents with improved and/or broader scope of pharmacological properties. This review focuses on the research advances thus far to identify the major scientific gaps and prospects. Peer-reviewed published data on the anti-diabetic effects of zinc(II) complexes were sourced from different scientific search engines, including, but not limited to “PubMed”, “Google Scholar”, “Scopus” and ScienceDirect to identify potent anti-diabetic zinc(II) complexes. The complexes were subcategorized according to their precursor ligands. A critical analysis of the outcomes from published studies shows promising leads, with Zn(II) complexes having a “tri-facet” mode of exerting pharmacological effects. However, the promising leads have been flawed by some major scientific gaps. While zinc(II) complexes of synthetic ligands with little or no anti-diabetic pharmacological history remain the most studied (about 72 %), their toxicity profile was not reported, which raises safety concerns for clinical relevance. The zinc(II) complexes of plant polyphenols; natural ligands, such as maltol and hinokitiol; and supplements, such as ascorbic acid (a natural antioxidant), L-threonine and L-carnitine, showed promising insulin mimetic and glycemic control properties but remain understudied and lack clinical validation, in spite of their minimal safety concerns and health benefits. A paradigm shift toward probing (including clinical studies) supplements, plant polyphenol and natural ligands as anti-diabetic zinc(II) complex is, therefore, recommended. Also, promising anti-diabetic Zn(II) complexes of synthetic ligands should undergo critical toxicity evaluation to address possible safety concerns. en_US
dc.language.iso en en_US
dc.publisher Pharmacological Research 155 (2020) 104744 en_US
dc.relation.ispartofseries Pharmacological Research;155 (2020) 104744
dc.subject Diabetes en_US
dc.subject Zinc complex en_US
dc.subject Plant polyphenol en_US
dc.subject Coordination mode en_US
dc.subject Partition coefficient en_US
dc.subject Insulin mimetic property en_US
dc.title A Comprehensive Review On Zinc(Ii) Complexes As Anti-Diabetic Agents: The Advances, Scientific Gaps And Prospects en_US
dc.type Article en_US


Files in this item

This item appears in the following Collection(s)

Show simple item record

Search DSpace


Browse

My Account