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Antifungal and Anti-Mycotoxigenic Activity of Selected South African Medicinal Plants Species

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dc.contributor.author Dikhoba, P.M.
dc.contributor.author Mongalo, N.I.
dc.contributor.author Elgorashi, E.E.
dc.contributor.author Makhafola, T.J.
dc.date.accessioned 2021-01-17T14:51:52Z
dc.date.available 2021-01-17T14:51:52Z
dc.date.issued 2019
dc.identifier.issn 2405-8440
dc.identifier.uri http://hdl.handle.net/11462/2168
dc.description Research Article en_US
dc.description.abstract Antifungal and anti-mycotoxigenic activity of 25 acetone leaf extracts of South African medicinal plants with potent antioxidant activity were investigated against three phytopathogenic fungal strains. The extracts exhibited varying degrees of in vitro anti-mycotoxigenic effect against Fusarium verticillioides, Aspergillus flavus and Aspergillus ochraceous. Markhamia obtusifolia (Baker) Sprague exhibited the lowest minimum inhibitory concentration (MIC) values as low as 0.08 mg/ml against Aspergillus flavus and Furasium verticilloides at both 24 and 48 hr incubation period, while Curtisia dentata exhibited similar MIC value against Aspergillus ochraceous. Curtisia dentata further yielded the highest total activity of 1583 ml/g against Aspergillus ochraceous at 24 and 48 hr incubation period. In the mycelial growth inhibition (MGI) evaluation, Fusarium verticilloides was more sensitive to plants extracts, while Kirkia wilmsii exhibited highest MGI of 50.08% against Fusarium verticilloides on the 6th day of incubation. Five acetone extracts from Acokanthora oppositifolia, Bauhinia galpinii, Combretum caffrum, Ricinus communis and Solanum aculeastrum exhibited lowest IC50 value of 0.01 mg/ml against (2,2’-azinobis-3-ethylbenzthiazoline-6- suphonic acid (ABTS). Curtisia dentata and Markhamia obtusifolia extracts were further subjected to gas chromatography mass-spectrophotometry (GC-MS) analysis. Curtisia dentata revealed the presence of triterpenoid compounds, β-amyrin (53.30%) and α-amyrin (6.42%), while Markhamia obtusifolia yielded the presence of neophytadiene (4.38%) and palmitic acid (3.61%) The results suggest that natural products from plants may well be used as possible substitutes for synthetic fungicides. Given the antifungal and antioxidant potential of the selected plants, they may have potential as possible leads for the development of biofungicides that may well prevent oxidation related food spoilage. en_US
dc.language.iso en en_US
dc.publisher Heliyon en_US
dc.relation.ispartofseries Heliyon;5 (2019) e02668
dc.subject Agriculture en_US
dc.subject Environmental Science en_US
dc.subject Plant Biology en_US
dc.subject Antifungal en_US
dc.subject Antioxidant Activity en_US
dc.subject Mycelial Growth Inhibition en_US
dc.subject Phyto-Compounds en_US
dc.subject Mycotoxins en_US
dc.title Antifungal and Anti-Mycotoxigenic Activity of Selected South African Medicinal Plants Species en_US
dc.type Article en_US

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