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Self-Assembled Lipid Cubic Phase and Cubosomes for the Delivery of Aspirin as a Model Drug

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dc.contributor.author Kulkarni, Chandrashekhar V.
dc.contributor.author Vishwapathi, Vinod Kumar
dc.contributor.author Quarshie, Abraham
dc.contributor.author Moinuddin, Zeinab
dc.contributor.author Page, James
dc.contributor.author Kendrekar, Pravin
dc.contributor.author Mashele, Samson S.
dc.date.accessioned 2018-12-05T06:21:01Z
dc.date.available 2018-12-05T06:21:01Z
dc.date.issued 2017
dc.identifier.uri http://hdl.handle.net/11462/1812
dc.description Published Article en_US
dc.description.abstract Three-dimensionally organized lipid cubic self-assemblies and derived oil-in-water emulsions called “cubosomes” are attractive for various biotechnological applications due to their ability to be loaded with functional molecules and their associated sustained release properties. Here, we employed both of these lipid-based systems for the delivery of a model drug, aspirin, under comparable conditions. Studies were performed by varying drug-to-lipid ratio and the type of release medium, water and phosphate buffer saline (PBS). Release rates were determined using UV−vis spectroscopy, and small-angle Xray scattering was used to confirm the type of self-assembled nanostructures formed in these lipid systems. The release from the bulk lipid cubic phase was sustained as compared to that of dispersed cubosomes, and the release in PBS was more efficient than in water. The tortuosity of the architecture, length of the diffusion pathway, type of nanostructure, and physicochemical interaction with the release media evidently contribute to these observations. This work is particularly important as it is the first report where both of these nanostructured lipid systems have been studied together under similar conditions. This work provides important insights into understanding and therefore controlling the release behavior of lipid-based drug nanocarriers. en_US
dc.format.extent 2 106 414 bytes, 1 file
dc.format.mimetype Application/PDF
dc.language.iso en_US en_US
dc.publisher Langmuir en_US
dc.title Self-Assembled Lipid Cubic Phase and Cubosomes for the Delivery of Aspirin as a Model Drug en_US
dc.type Article en_US

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