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L-Pyrrolidine-2-Carboxylic Acid Sulfate: A New Ionic Liquid for the Synthesis of Bioactive Tetrahydrobenzo[b]pyrans

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dc.contributor.author Godse, Vaibhav W.
dc.contributor.author Sonwane, Umesh R.
dc.contributor.author Pawar, Parmeshwar P.
dc.contributor.author Rindhe, Sahebrao S.
dc.contributor.author Kendrekar, Pravin S.
dc.contributor.author Pawar, Rajendra P.
dc.date.accessioned 2018-08-31T08:02:01Z
dc.date.available 2018-08-31T08:02:01Z
dc.date.issued 2017
dc.identifier.issn 0030-4948
dc.identifier.issn 1945-5453
dc.identifier.uri http://hdl.handle.net/11462/1631
dc.description Published Article en_US
dc.description.abstract Multicomponent reactions (MCRs), a significant subclass of reac tions, are one-pot processes in which three or four easily-approachable components react to form a single product. The methodology is a powerful synthetic tool for the preparation of important drugs and other biologically active compounds. 1 MCRs have been useful in the development of environ- mentally-friendly and less expensive procedure s for the generation of libraries of heterocy- clic compounds 2 and the development of MCRs can le ad to new, efficient, synthetic methodologies. Tetrahydrobenzo[b]pyrans an d their derivatives are an important class of heterocyclic compounds with antic oagulant, antitumor, spasmoly tic, antibacterial, diuretic, potassium channel activating and insulin-sensitizing activities. 3–6 4H-Benzo[b]pyrans are usually synthesized from a -cyano cinnamonitrile derivatives with dimedone catalyzed by acid or base. 7 Recently MCRs have been used for their preparation. As compared to the conventional linear step synthesis, they can make the process easier, reduce time, save money, energy, and raw materials, resulting in both economic and environmental bene- fits. 8–9 A number of methods have been reported using dimedone, aromatic aldehydes and malononitrile in the presence of catalysts, such as CeCl 3 ¢ 7H 2 O, 10 N-methylimidazole, 11 tet- ramethyl ammonium hydroxide, 12 MgO, 13 amines, 14 2,2,2-trifluoroethanol, 15 and TiO 2 . 16 Other methods have involved microwave heating, 17 ultrasonic irradiation, 18 electrosynthe- sis, 19 hexadecyldimethylbenzylammonium bromide (HDMBAB), 20 Na 2 SeO 4 , 21 DABCO, 22 en_US
dc.format.extent 2 147 371 bytes, 1 file
dc.format.mimetype Application/PDF
dc.language.iso en_US en_US
dc.publisher Organic Preparations and Procedures International: The New Journal for Organic Synthesis en_US
dc.relation.ispartofseries Volume 49;
dc.title L-Pyrrolidine-2-Carboxylic Acid Sulfate: A New Ionic Liquid for the Synthesis of Bioactive Tetrahydrobenzo[b]pyrans en_US
dc.type Article en_US

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