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Copper Acyl Salicylate Has Potential as an Anti-Cryptococcus Antifungal Agent

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dc.contributor.author Ogundeji, A.O.
dc.contributor.author Porotloane, B.F.
dc.contributor.author Pohl, C.H.
dc.contributor.author Kendrekar, P.S.
dc.contributor.author Sebolai, O.M.
dc.date.accessioned 2018-08-16T13:08:29Z
dc.date.available 2018-08-16T13:08:29Z
dc.date.issued 2018
dc.identifier.issn 0066-4804
dc.identifier.issn 1098-6596
dc.identifier.uri http://hdl.handle.net/11462/1507
dc.description Published Article en_US
dc.description.abstract The in vitro antifungal activity of aspirin against cryptococcal cells has been reported. However, the unwanted effects of aspirin may limit its clinical application. Conceivably, a derivative of aspirin could overcome this challenge. Toward this end, this study considered the usage of an aspirinate-metal complex, namely, copper acyl salicylate (CAS), as an anti-Cryptococcus antifungal agent. Additionally, the study examined the effects of this compound on macrophage function. The in vitro susceptibility results revealed that cryptococcal cells were vulnerable (in a dose-dependent manner) to CAS, which might have effected growth inhibition by damaging cryptococcal cell membranes. Interestingly, when CAS was used in combination with fluconazole or amphotericin B, synergism was observed. Furthermore, CAS did not negatively affect the growth or metabolic activity of macrophages; rather, it sensitized those immune cells to produce interferon gamma and interleukin 6, which, in turn, might have aided in the phagocytosis of cryptococcal cells. Compared to our aspirin data, CAS was noted to be more effective in killing cryptococcal cells (based on susceptibility results) and less toxic toward macrophages (based on growth inhibition results). Taking these findings together, it is reasonable to conclude that CAS may be a better anti-Cryptococcus drug that could deliver better therapeutic outcomes, compared to aspirin. en_US
dc.format.extent 10 223 852 bytes, 1 file
dc.format.mimetype Application/PDF
dc.language.iso en_US en_US
dc.publisher Antimicrob Agents Chemother en_US
dc.title Copper Acyl Salicylate Has Potential as an Anti-Cryptococcus Antifungal Agent en_US
dc.type Article en_US

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